The mission of the Biobank working group is to promote standardized biospecimen collection, annotation, and storage for specimens from both mouse models and human patients to enable optimal characterization by current and emerging analytic approaches. We will accomplish this mission by sharing methods for tissue biobanking and processing of other specimen types across participating sites. We will also conduct comparative studies to identify best practices for biobanking procedures when these are not readily apparent.
Chair: Jonathan Nowak (Dana-Farber Cancer Institute)
Co-Chair: Mojgan Hosseini (University of California San Diego)
Members:
Susan Tsai (Medical College of Wisconsin)
Tapan Bera (National Cancer institute)
Arvind Rao (University of Michigan)
Jeanine Genkinger (Columbia University)
The mission of the Correlative Studies and Platform Models working group is to expand access to standard operating procedures and new technologies aimed at furthering understanding of the pancreatic cancer stromal microenvironment in both mouse models and human patients. Within the consortium, we will provide training opportunities for learning new techniques at each of our participating sites. We will also make methods and protocols publicly available to disseminate best practices throughout the pancreatic cancer research community.
Chair: Stephanie Dougan (Dana-Farber Cancer Institute)
Co-Chair: Melissa Fishel (Indiana University)
Members:
Andrew Lowy (University of California San Diego)
Natalia Mercer (National Cancer institute)
Costas Lyssiotis (University of Michigan)
Arvind Rao (University of Michigan)
Subrata Sen (UT MD Anderson Cancer Center)
Anita Turk (Indiana University)
Alex Shalek (Dana-Farber Cancer Institute)
Gulam Manji (Columbia University)
Cara Haymaker (UT MD Anderson Cancer Center)
The mission of the Bioinformatics/Biostatistics working group is to integrate big data and computational tools for a better understanding of the tumor microenvironment in pancreatic cancer. Our long-term goal is to create an eco-community for archiving, analyzing, visualizing, and disseminating omics data within PSRC. We will catalog data and analytic resources within the consortium, standardize analysis methods and pipelines, and generate analysis scripts for sharing across participating sites. We also aim to perform integrative analysis using data and tools collected to address biological and clinical questions.
Chair: Xianlu (Laura) Peng (UNC-Chapel Hill)
Co-Chair: Chi Zhang (Oregon Health & Science University)
Members:
Linghua Wang (UT MD Anderson Cancer Center)
Jack Lee (UT MD Anderson Cancer Center)
Arvind Rao (University of Michigan)
Steve Nothwehr (National Cancer institute)
Naim Rashid (UNC-Chapel Hill)
Alex Shalek (Dana-Farber Cancer Institute)
Waree Rinsurongkawong (UT MD Anderson Cancer Center)
Nina G. Steele (Henry Ford Hospital)
Alvaro Curiel Garcia (Columbia University)
Soumya Korrapati (National Cancer institute)
Sha Cao (Oregon Health & Science University)
The mission of the Cell States and Function working group is to establish a general consensus framework for classifying the various cells present in the PDAC the tumor microenvironment, namely the various fibroblast and immune populations. Given the numerous different nomenclature that have arisen in the past several years, we will accomplish this by consulting with expert opinion and placing the greatest weight on cells types that have been validated with functional studies that emphasize biological relevance (in vivo veritas). We will also attempt to define the role of plasticity in maintaining homeostasis in the microenvironment. We will publish our collective efforts in a white paper as a reference for the PDAC stromal field.
Chair: Ken Olive (Columbia University)
Co-Chair: Eileen Carpenter (University of Michigan)
Members:
Andrea Califano (Columbia University)
Howard Crawford (Henry Ford)
Jeff Hildesheim (National Cancer institute)
Arvind Rao (University of Michigan)
Timothy Frankel (University of Michigan)
Nicholas Arpaia (Columbia University)
Anirban Maitra (UT MD Anderson Cancer Center)
Celeste Simon (University of Pennsylvania)
Alex Shalek (Dana-Farber Cancer Institute)
Robert Schwabe (University of California San Diego)
Cara Haymaker (UT MD Anderson Cancer Center)