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About Us

Pancreatic Cancer Stromal Reprogramming Consortium (PSRC)

The PSRC aims to develop a multidisciplinary community of pancreatic ductal adenocarcinoma (PDAC) researchers that will expand upon traditional tumor-centric studies and ongoing immuno-oncology efforts. The network is focusing on the identification, integration, and mechanistic evaluation of additional tumor microenvironment (TME) elements driving PDAC progression and response to therapy.

PSRC also aims to adopt a comprehensive “Tumor-TME Co-Organizer” research model in the pursuit of novel biology-backed targets involved in modulating multi-directional tumor-microenvironment dynamics. This expansion is designed to expose new biology-backed vulnerabilities that will inform the design and testing of more effective combinatorial approaches in pre-clinical platforms and near future clinical evaluation.

U01 Institutions
Funded Projects

PSRC Research Projects (U01s)

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Kenneth P. Olive, Gulam A. Manji

Elucidation and targeting of paracrine cascades in PDAC

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William C Hahn, Andrew J. Aguirre, Stephanie Dougan

Stromal modulation of pancreatic malignant cell state and therapeutic sensitivity

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Bumsoo Han, Melissa L. Fishel, Matthew J. Flick

Reprogramming PDAC stroma by targeting coagulation in the tumor microenvironment

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Michael Karin, Andrew M. Lowy, Robert F. Schwabe, Mojgan Hosseini

Regulation of PDAC metabolism and immunity by collagen and its cleavage products

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Marina Pasca Di Magliano, Howard C. Crawford, Timothy L. Frankel, Costas A. Lyssiotis

Fibroblast orchestration of the immune response in pancreatic cancer

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Jen Jen Yeh, Naim Ur Rashid, Susan Tsai

Integrating tumor and stroma to understand and predict treatment response

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PSRC Coordinating and Data Management Center (U24)

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Anirban Maitra, Jack Lee

PASSCODE (Pancreatic Adenocarcinoma Stromal Reprogramming Consortium Coordination, Data Management and Education)

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