Kenneth P. Olive, Gulam A. Manji
Elucidation and targeting of paracrine cascades in PDAC
Read MoreThe PSRC aims to develop a multidisciplinary community of pancreatic ductal adenocarcinoma (PDAC) researchers that will expand upon traditional tumor-centric studies and ongoing immuno-oncology efforts. The network is focusing on the identification, integration, and mechanistic evaluation of additional tumor microenvironment (TME) elements driving PDAC progression and response to therapy.
PSRC also aims to adopt a comprehensive “Tumor-TME Co-Organizer” research model in the pursuit of novel biology-backed targets involved in modulating multi-directional tumor-microenvironment dynamics. This expansion is designed to expose new biology-backed vulnerabilities that will inform the design and testing of more effective combinatorial approaches in pre-clinical platforms and near future clinical evaluation.
William C Hahn, Andrew J. Aguirre, Stephanie Dougan
Stromal modulation of pancreatic malignant cell state and therapeutic sensitivity
Read MoreBumsoo Han, Melissa L. Fishel, Matthew J. Flick
Reprogramming PDAC stroma by targeting coagulation in the tumor microenvironment
Read MoreMichael Karin, Andrew M. Lowy, Robert F. Schwabe, Mojgan Hosseini
Regulation of PDAC metabolism and immunity by collagen and its cleavage products
Read MoreMarina Pasca Di Magliano, Howard C. Crawford, Timothy L. Frankel, Costas A. Lyssiotis
Fibroblast orchestration of the immune response in pancreatic cancer
Read MoreJen Jen Yeh, Naim Ur Rashid, Susan Tsai
Integrating tumor and stroma to understand and predict treatment response
Read MoreAnirban Maitra, Jack Lee
PASSCODE (Pancreatic Adenocarcinoma Stromal Reprogramming Consortium Coordination, Data Management and Education)
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